منابع مشابه
A 47,XXq-Y Klinefelter male.
Case Report The patient was first seen by one of us (G.N.R.) when he was in St Martha's Hospital being treated for viral hepatitis. He is a dull-looking boy with a rather large build for his age. The lower jaw is prominent, the hands are large, and there is gynaecomastia on both sides. He also shows sinus bradycardia. Body hair has a feminine distribution. The testes are small and soft and a bi...
متن کاملXXY male mice: an experimental model for Klinefelter syndrome.
Klinefelter syndrome (47,XXY) is the most common sex chromosome aneuploidy in men. Thus, it is important to establish an experimental animal model to explore its underlying molecular mechanisms. Mice with a 41,XXY karyotype were produced by mating wild-type male mice with chimeric female mice carrying male embryonic stem cells. The objectives of the present study were to characterize the testic...
متن کاملCarcinoma of Male Breast in Association with the Klinefelter Syndrome.
Carcinoma of the male breast is a comparatively rare form of malignantdisease, representing about 0.2% of all male cancer. Among 11,543 cases of carcinoma of the breast seen at the Christie Hospital and Holt Radium Institute, Manchester, between 1945 and 1959, 110 (0.95%) were in males. Other records seem to show precisely the same proportion, suggesting a similar aetiological background for br...
متن کاملY chromosome and male infertility.
Recent genome analysis of the Y chromosome has increased the number of genes found on this chromosome markedly. Many of these genes in the part of the Y chromosome that does not undergo recombination with the X chromosome are members of gene families. Evolutionary considerations imply that genes on the Y chromosome will degenerate unless they have male advantageous or female deleterious functio...
متن کاملKlinefelter-like phenotype and primary infertility in a male with a paracentric Xq inversion.
Klinefelter syndrome is an abnormality of sexual development which is usually characterised by the chromosome complement 47,XXY. We present a case of a male patient with the phenotypic appearance of Klinefelter syndrome and primary infertility, who was found, on karyotype analysis, to have a hitherto undescribed inversion of the long arm of the X chromosome (46,Y,inv(X)(q12q25)). The underlying...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1971
ISSN: 1468-6244
DOI: 10.1136/jmg.8.4.530